Rapid whole-genome sequencing decreases infant morbidity and cost of hospitalization
نویسندگان
چکیده
منابع مشابه
Whole-Genome Sequencing Breaks the Cost Barrier
The ever-decreasing cost of sequencing is ushering in a new era in genomic medicine. Laura Bonetta reports on new studies that provide a glimpse of the opportunities ahead.
متن کاملRapid single-colony whole-genome sequencing of bacterial pathogens
OBJECTIVES As a result of the introduction of rapid benchtop sequencers, the time required to subculture a bacterial pathogen to extract sufficient DNA for library preparation can now exceed the time to sequence said DNA. We have eliminated this rate-limiting step by developing a protocol to generate DNA libraries for whole-genome sequencing directly from single bacterial colonies grown on prim...
متن کاملRapid whole-genome mutational profiling using next-generation sequencing technologies.
Forward genetic mutational studies, adaptive evolution, and phenotypic screening are powerful tools for creating new variant organisms with desirable traits. However, mutations generated in the process cannot be easily identified with traditional genetic tools. We show that new high-throughput, massively parallel sequencing technologies can completely and accurately characterize a mutant genome...
متن کاملComparing whole genome sequencing and exome sequencing
Introduction Next-generation DNA sequencing empowers scientists to identify genetic variations associated with human disease at higher resolution and greater sensitivity than previously possible. Two approaches are commonly employed -exome sequencing and whole genome sequencing. Exome sequencing targets protein-coding regions comprising approximately 1% of the human genome, while whole genome s...
متن کاملWhole exome and whole genome sequencing.
PURPOSE OF REVIEW The purpose of this review is to describe the new DNA sequencing technologies referred to as next-generation sequencing (NGS). These new methods are becoming central to research in human disease and are starting to be used in routine clinical care. RECENT FINDINGS Advances in instrumentation have dramatically reduced the cost of DNA sequencing. An individual's entire genome ...
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ژورنال
عنوان ژورنال: npj Genomic Medicine
سال: 2018
ISSN: 2056-7944
DOI: 10.1038/s41525-018-0049-4